Aim of the study:The present investigation was carried out to highlight the hepatoprotective activity of PAEDERIA FOETIDA leaves against liver cirrhosis\r\nMaterials and Methods: The ethanolic extract of Paederia foetida leaves subjected to acute toxicity studies as per OECD guidelines 423, and based on the report two doses (250/500mg/kg b.wt) were fixed for pharmacological studies. Liver cirrhosis was induced by carbon tetra chloride (2.4ml/kg b.wt).Five groups of wistar rats of six animals in each group was allocated.The parameters changes in liver weight, ascites volume, biochemical estimation and glycogen determination were performed. \r\nResults & discussion: The extract successfully showed the hepatoprotective effect in dose dependent manner and was statistically significant by oneway ANOVA followed apost hoc Bonferroni test.
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